A Conserved Asparagine Residue in Tm1 of the Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport
نویسندگان
چکیده
L. Keith Henry, Hideki Iwamoto, Julie R. Field, Kristian Kaufmann, Eric S. Dawson, Miriam T. Jacobs, Chelsea Adams, Bruce Felts, Igor Zdravkovic, Vanessa Armstrong, Steven Combs, Ernesto Solis, Gary Rudnick, Sergei Y. Noskov, Louis J. DeFelice, Jens Meiler & Randy D. Blakely Departments of Pharmacology, Chemistry, Biochemistry and Psychiatry, Center for Molecular Neuroscience, Center for Structural Biology, Vanderbilt Center for Neuroscience Drug Discovery Vanderbilt Univ. School of Medicine, Nashville, TN 37232-8548, Department of Pharmacology, Yale Univ. School of Medicine, New Haven, CT 06520-8066, Department of Pharmacology, Physiology and Therapeutics, Univ of North Dakota, Grand Forks, ND 58203,Institute for Biocomplexity and Informatics, Department of Biological Sciences, Univ of Calgary, Calgary, Canada, T2N 1N4
منابع مشابه
Review of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells . The role of this neurotransmitter is important and involves control of sexual behaviors, morality, sleep, pain, appetite, aggression, cardiovascular function and regulation of gut fu...
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